However, estrone is a form of unhealthy estrogen that raises the risk of cancers. Estriol or oestriol E3 refers to a form of estrogen, which is a metabolite of estradiol. Hence, it is formed during the estradiol and estrone metabolism.
It is produced in the liver and placenta. The binding of estriol with the estrogen receptor blocks the binding of strong estradiol with the receptor.
Hence, estriol exhibits both estrogenic as well as the antiestrogenic actions. By this, estriol reduces the cancer-risk of estradiol. The formation of estriol is shown in figure 1. Figure 1: Formation of Estriol. Estriol is important for healthy skin and mucous membranes. It is given as a drug in hormone replacement therapy. The application of estriol on the skin increases the levels of collagen and hydrates the skin cells. It is given as a supplement for vaginal dryness during menopause.
The levels of Hydroxyesterone is a breakdown product of estriol, and it can be elevated in women who receive oral estriol. However, it can increase the risk of both cervical and breast cancers. Estradiol E2 or oestradiol refers to the major form of estrogen produced in the ovaries.
It is the most potent or the strongest form of estrogen. Hence, even a small quantity of estradiol has a very high effect. Estradiol can be produced during the metabolism of various types of precursors in the adrenal glands.
Abstract While conventional hormone replacement therapy provides certain benefits, it is not without significant risks. Publication types Review. Substances Estrogens Estriol. When you combine estriol with estradiol you can get the beneficial effects of estradiol and estriol, without the negative side effects of estradiol. Also, estriol is excellent for the skin and mucous membranes. Often, we use estriol for vaginal dryness during menopause.
It is very beneficial for vaginal atrophy and pain with intercourse without any adverse effects. We also use it for wrinkles and skin integrity. Applying estriol topically can increase collagen and hydrate cells, which makes it especially great for reducing wrinkles.
Unfortunately, estriol is not available commercially. You are not going to get estriol hormone replacement from your primary care doctor or gynecologist. You are not going to get estriol from your big box pharmacy. However, Functional Medicine doctors that specialize in bioidentical hormone replacement will be very familiar with estriol and estradiol.
We use a combination of estriol and estradiol, which is known as Biest for hormone replacement. Biest and estriol are both available from compounding pharmacies. With compounding pharmacies, we can prescribe almost any dosing of Biest that we want based on the particular needs of the patient.
Hopefully, this has been informative and helpful to you. If you have any questions or personal stories, please feel free to email us at help progressyourhealth.
You say estriol is not available commercially but I bought some on the intrnet. Is it not really estriol? By commercially, we mean there are no branded prescriptions available through pharmacies like CVS or Walgreens.
You can by Estriol, but typically it needs a prescription and is filled by a compounding pharmacy.
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